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Home Antibody All anti-ENDOG antibodies

Anti-ENDOG Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306105
  • Rabbit Polyclonal EndoG Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417987) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenEndoG antibody was raised with a synthetic peptide corresponding to 15 amino acids near the amino terminus of human EndoG.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens endonuclease G (ENDOG)
Alternative NameFLJ27463
Database LinkNP_004426
FunctionThe fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (endoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD (1,2). EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in C. elegans (2). EndooG also cleaves DNA in vitro (4).
Related Pathway

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WB Image
Western blot analysis of EndoG in mouse (M) 3T3 and human (H) HepG2 cell lysates with EndoG antibody at 2 ug/ml.
IHC Image
Immunohistochemistry of EndoG in human pancreas with EndoG antibody at 15 ug/ml.

 

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