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Anti-ENC1 Antibody EPR5406(B)
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Also for ENC1 (NM_001256574)
|A synthetic peptide corresponding to residues in human ENC1 was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:1,000 - 10,000; IHC 1:50 - 100; ICC: 1:100 - 250;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens ectodermal-neural cortex 1 (with BTB domain) (ENC1), transcript variant 2|
|CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10|
|DNA damage and/or hyperproliferative signals activate wild-type p53 tumor suppressor protein (TP53), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. ENC1 is a redox-controlling protein. Reactive oxygen species (ROS) are noted to be potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. ENC1 is also an actin-binding protein (1).|
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Western blot analysis on fetal brain lysate using anti-ENC1 RabMAb.
Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-ENC1 RabMAb.