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Anti-EIF4EBP1 Antibody Y330
Also for EIF4EBP1 (NM_004095)
|A synthetic peptide corresponding to residues near the C-term of human4E-BP1 was used as immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000; IHC-P: Use at an assay dependent dilution; FC: 1:20; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for ICC.
|Homo sapiens eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1)|
|4E-BP1; 4EBP1; BP-1; PHAS-I|
Entrez Gene 1978 Human
|4E-BP1 (eIF4E-binding protein) also known as PHAS, is a 10-12 kDa acidic protein that compete with eIF4G for binding of eiF4E to the mRNA 5’ cap structure (1). Binding of the 4E-BPs to eIF4E is reversible and is dependent on the phosphorylation status of 4E-BP. Non-phosphorylated 4E-BP1 will bind strongly to eiF4E while, the phosphorylated form will not (2). Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating 4E-BP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the 4EBP1-eIF4E interaction (3-4) |
| ErbB signaling pathwaymTOR signaling pathwayInsulin signaling pathwayAcute myeloid leukemia|
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Western blot - eIF4EBP1 antibody [Y330]; Anti-eIF4EBP1 antibody [Y330] at 1/1000 dilution + K562 cell lysate.Predicted band size : 12 kDa.Observed band size : 18 kDa .
Immunohistochemistry (Paraffin-embedded sections) - eIF4EBP1 antibody [Y330]; TA300506, staining human prostate carcinoma by immunohistochemistry, Paraffin embedded tissue