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Home Antibody All anti-EIF4EBP1 antibodies

Anti-EIF4EBP1 Antibody Y330

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300506
  • Rabbit Monoclonal Antibody against EIF4EBP1 (Clone Y330)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401322) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for EIF4EBP1 (NM_004095)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-term of human4E-BP1 was used as immunogen.
Clone NameY330 IsotypeIgG fraction
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000; IHC-P: Use at an assay dependent dilution; FC: 1:20; IP: 1:50
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC.

Reference Data

Target NameHomo sapiens eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1)
Alternative Name4E-BP1; 4EBP1; BP-1; PHAS-I
Database LinkNP_004086
Function4E-BP1 (eIF4E-binding protein) also known as PHAS, is a 10-12 kDa acidic protein that compete with eIF4G for binding of eiF4E to the mRNA 5’ cap structure (1). Binding of the 4E-BPs to eIF4E is reversible and is dependent on the phosphorylation status of 4E-BP. Non-phosphorylated 4E-BP1 will bind strongly to eiF4E while, the phosphorylated form will not (2). Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating 4E-BP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the 4EBP1-eIF4E interaction (3-4)
Related Pathway

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WB Image
Western blot - eIF4EBP1 antibody [Y330]; Anti-eIF4EBP1 antibody [Y330] at 1/1000 dilution + K562 cell lysate.Predicted band size : 12 kDa.Observed band size : 18 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - eIF4EBP1 antibody [Y330]; TA300506, staining human prostate carcinoma by immunohistochemistry, Paraffin embedded tissue

 

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