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Home Antibody All anti-EIF4E antibodies

Anti-EIF4E TRUEMAB Antibody Clone 5D11

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA503042
  • EIF4E mouse monoclonal antibody,clone 5D11
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400723) , 20ug
100ul 325 In Stock
CF503042
  • Carrier-free (BSA/glycerol-free) EIF4E mouse monoclonal antibody,clone 5D11
100ug $450 3-4 weeks
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WB(1)
IHC(3)
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Also for EIF4E (NM_001968)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human EIF4E(NP_001959) produced in HEK293T cell.
Clone NameClone 5D11 IsotypeIgG1
Species ReactivityHuman Concentration0.5mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:2000, IHC 1:150,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens eukaryotic translation initiation factor 4E (EIF4E), transcript variant 1
Alternative NameAUTS19; CBP; EIF4E1; EIF4EL1; EIF4F
Database LinkNP_001959
FunctionAll eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G (MIM 600495) (Rychlik et al., 1987 [PubMed 3469651]).[supplied by OMIM].
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY EIF4E (RC207333, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-EIF4E.
IHC Image
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-EIF4E mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA503042)
IHC Image
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-EIF4E mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA503042)
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-EIF4E mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA503042)

 

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