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Home Antibody All anti-EIF2AK3 antibodies

Anti-EIF2AK3 Antibody

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SKU Description Amount Price Availability*  
TA322705 Anti-EIF2AK3 Rabbit Polyclonal Antibody 100ul $325 2-3 Weeks
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IHC(1)
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Also for EIF2AK3 (NM_004836)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFusion protein corresponding to C terminal 250 amino acids of human eukaryotic translation initiation factor 2-alpha kinase 3
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:1000-5000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Alternative NamePEK; PERK; WRS
Database LinkNP_004827
Entrez Gene 9451 Human
Entrez Gene 13666 Mouse
Entrez Gene 29702 Rat
FunctionThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2); leading to its inactivation; and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER); where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Related PathwayProtein KinaseSecreted ProteinTransmembraneDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Predicted cell location: Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human lung cancer tissue using EIF2AK3 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x200)
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