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Home Antibody All anti-EIF2AK2 antibodies

Anti-EIF2AK2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA321526
  • Anti-EIF2AK2 Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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IHC(1)
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Also for EIF2AK2 (NM_002759)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region derived from 438-451 amino acids of Human eukaryotic translation initiation factor 2-alpha kinase 2
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration2.2mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:2000-10000, IHC: 1:50-200
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), transcript variant 1
Alternative NameEIF2AK1; PKR; PRKR
Database LinkNP_002750
FunctionThe protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1; which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene
Related Pathway

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IHC Image
Predicted cell location: Cytoplasm. Positive control: Human breast cancer tissue. Recommended dilution: 1/50-200 The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using EIF2AK2 antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification:x200)

 

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