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Home Antibody All anti-EIF2AK2 antibodies

Anti-EIF2AK2 Antibody YE350

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SKU Description Amount Price Availability*  
TA300449 Rabbit Monoclonal Antibody against EIF2AK2 (Clone YE350) 100ul $325 In Stock
LC400976 EIF2AK2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues following the first double-stranded RNA-binding domain of human PKR was used as immunogen. The antibody does not cross-react with other GCN2 family members.
Clone NameYE350 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1: 1,000-5,000; IHC: 1:250-500; ICC: 1:250-500; IP: 1: 100
Predicted MW Explanation 62 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), transcript variant 1
Alternative NameEIF2AK1; PKR; PPP1R83; PRKR
Database LinkNP_002750
Entrez Gene 5610 Human
FunctionProtein kinase R (PKR) is a serine/threonine kinase that is induced by interferon and activated by double-stranded RNA. Upon activation, PKR is autophosphorylated at multiple sites and phosphorylates the a-subunit of the eukaryotic initiation factor-2 eIF2 (eIF2a), inhibiting protein synthesis (1,2). PKR controls the activation of several transcription factors (1) and mediates the effects of interferon via its capacity to inhibit protein synthesis (2). It has been shown that the autophosphorylation sites Thr-446 and Thr-451 in the activation loop of Human PKR are critical for its kinase activity (3).
Related PathwayProtein KinaseTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - PKR antibody [YE350]; Anti-PKR antibody [YE350] at 1/5000 dilution + HeLa cell lysate.Predicted band size : 62 kDa.Observed band size : 68 kDa .
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Immunohistochemistry (Paraffin-embedded sections) - PKR antibody [YE350]; Immunohistochemical analysis of paraffin-embedded human stomach carcinoma using TA300449 at 1/250 dilution.
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Immunocytochemistry/ Immunofluorescence - PKR antibody [YE350]; Immunofluorescent staining of HeLa cells using TA300449 at 1/250 dilution.
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