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Anti-EHMT2 Antibody EPR4018(2)
Also for EHMT2 (NM_025256)
|A synthetic peptide corresponding to residues in human G9a was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
|pH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens euchromatic histone-lysine N-methyltransferase 2 (EHMT2), transcript variant 3|
|BAT8; C6orf30; G9A; GAT8; KMT1C; NG36|
Entrez Gene 10919 Human
|G9a is a histone methyltransferase that preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. G9a is probably targeted to histone H3 by different DNA-binding proteins (1). G9a is also required for the efficient repression of developmentally regulated genes during embryonic stem cell differentiation (2). It is localized in the nucleus, where it associates with euchromatic regions but not heterochromatin (1).|
|Druggable Genome Lysine degradation|
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Western blot - Anti-KMT1C / G9a antibody [EPR4018(2)]; All lanes : Anti-KMT1C / G9a antibody [EPR4018(2)] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 132 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KMT1C / G9a antibody [EPR4018(2)]; Immunohistochemical analysis of paraffin-embedded Human carcinoma of thyroid gland tissue labelling KMT1C / G9a with TA307041 at 1/50 dilution.