Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 3
Synonyms:
ERBB; ERBB1; HER1; mENA; PIG61
Immunogen
A phospho specific peptide corresponding to residues surrounding threonine 678 of human EGFR was used as an immunogen. This antibody detects EGFR phosphorylated on thr678.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq].
Related Pathway
Adherens junction
Cytokine-cytokine receptor interaction
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
Focal Adhesion
MAPK signaling pathway
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Western blot analysis on A431 cell lysates using anti-Phospho-EGFR (pT678) RabMAb (TA303494), 1:50,000 dilution. Cells were either (A) untreated (B) treated with EGF
