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Home Antibody All anti-EDA2R antibodies

Anti-EDA2R Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306331
  • Rabbit Polyclonal XEDAR Antibody
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(1)

OriGene Data

ImmunogenXEDAR antibody was raised against recombinant human XEDAR.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ectodysplasin A2 receptor (EDA2R), transcript variant 2
Alternative NameEDA-A2R; EDAA2R; TNFRSF27; XEDAR
Database LinkNP_068555
Entrez Gene 60401 Human
FunctionX-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2) (1). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways (2). Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis (3). The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment (3).
Related PathwayTransmembraneTranscription FactorsDruggable Genome Cytokine-cytokine receptor interaction

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of XEDAR in 293 cell lysate with XEDAR antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
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Immunohistochemistry of XEDAR in human skin tissue with XEDAR antibody at 10 ug/ml.
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