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Home Antibody All anti-ECSIT antibodies

Anti-ECSIT Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306185
  • Rabbit Polyclonal ECSIT Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens ECSIT signalling integrator (ECSIT), transcript variant 2
Alternative NameSITPEC
Database LinkNP_001135936
FunctionActivation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.
Related Pathway
MAPK signaling pathway

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WB Image
Western blot analysis of ECSIT in human heart cell lysates with ECSIT antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of ECSIT in mouse heart cells with ECSIT antibody at 2 ug/ml.

 

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