Home Antibody All anti-ECSIT antibodies
Also for ECSIT (NM_001142464)
|ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens ECSIT signalling integrator (ECSIT), transcript variant 2|
Entrez Gene 51295 Human
Entrez Gene 26940 Mouse
|Activation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.|
| MAPK signaling pathway|
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Western blot analysis of ECSIT in human heart cell lysates with ECSIT antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry of ECSIT in mouse heart cells with ECSIT antibody at 2 ug/ml.