OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-EBI3 antibodies

Anti-EBI3 Antibody

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306705
  • Rabbit Polyclonal EBI3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417095) , 20ug Explanation
100ug 325 3-7 Days
Add to Shopping Cart
WB(1)
IHC(1)
spacer
Also for EBI3 (NM_005755)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenEBI3 antibody was raised against a 16 amino acid peptide from near the center of human EBI3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Epstein-Barr virus induced 3 (EBI3)
Alternative NameIL-27B; IL27B
Database LinkNP_005746
Entrez Gene 10148 Human
Entrez Gene 50498 Mouse
Entrez Gene 680609 Rat
FunctionEBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-g, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.
Related PathwaySecreted ProteinDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of EBI3 in rat spleen tissue lysate with EBI3 antibody at 2 ug/mL.
IHC Image
Immunohistochemistry of EBI3 in human spleen tissue with EBI3 antibody at 2.5 ug/mL.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title