Home Antibody All anti-E2F4 antibodies
Also for E2F4 (NM_001950)
|internal region of NP_001941.2 (PKELSEIFDPTR)|
|Test: Human. Expected from seq similarity: Human, Mouse, Dog, Pig, Cow
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
|Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4)|
Entrez Gene 1874 Human
Entrez Gene 104394 Mouse
Entrez Gene 611243 Dog
|The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008].|
|Transcription FactorsDruggable Genome Cell cycleTGF-beta signaling pathway|
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E2F4 antibody (0.3µg/ml) staining of A43 (A) and HeLa (B) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.