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Home Antibody All anti-Dlg3 antibodies

Anti-Dlg3 Antibody S19-2

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326526
  • Mouse Monoclonal Anti-SAP102 Antibody
100µg 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenFusion protein amino acids 1-120 of rat SAP102
Clone NameS19-2 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 (ECL)
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects ~105kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.

Reference Data

Target NameRattus norvegicus discs, large homolog 3 (Drosophila) (Dlg3)
Alternative NameDlgh3
Database LinkNP_113827
Entrez Gene 1741 Human
Entrez Gene 53310 Mouse
Entrez Gene 58948 Rat
FunctionSynapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal . SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain . All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway . SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains . In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
Related Pathway

* Availability is in business days
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WB Image
Western blot analysis of SAP102 in rat brain extract using a dilution of 1:1000 of the antibody

 

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