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Home Antibody All anti-Dffa antibodies

Anti-Dffa Antibody

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SKU Description Amount Price Availability*  
TA305968
  • Rabbit Polyclonal ICAD Antibody
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenICAD antibody was raised against a peptide corresponding to amino acids near the amino terminus of mouse ICAD .
Clone Name IsotypeIgG
Species ReactivityMouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameMus musculus DNA fragmentation factor, alpha subunit (Dffa), transcript variant 2
Alternative NameA330085O09Rik; DFF35; Dff45; ICAD; ICAD-L; ICAD-S
Database LinkNP_034174
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which is cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF was identified as a DNase inhibitor designated ICAD, for inhibitor of caspase-activated DNase. Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death.
Related Pathway

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WB Image
Western blot analysis of ICAD in mouse lung tissue lysate with ICAD antibody at 1 ug/ml.
IHC Image
Immunohistochemistry of ICAD in murine lung tissue with ICAD antibody at 2 ug/ml.

 

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