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Anti-DcR1 Antibody EPR6162
Also for DcR1 (NM_003841)
|A synthetic peptide corresponding to residues in human DcR1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250; FC: 1:100 - 1:500
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for IHC-P or IP.
|Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C)|
|CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID|
Entrez Gene 8794 Human
|DcR1 is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. DcR1 is not capable of inducing apoptosis, and it is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. It was found to be a p53-regulated DNA damage-inducible protein. The expression of DcR1 was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL (1).|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionApoptosisNatural killer cell mediated cytotoxicity|
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Western blot - Anti-DcR1 antibody [EPR6162]; All lanes : Anti-DcR1 antibody [EPR6162] at 1/1000 dilution.Lane 1 : Human spleen lysate.Lane 2 : JAR cell lysate.Lane 3 : Human tonsil lysate.Lane 4 : Jurkat cell lysate.Lane 5 : A549 cell lysate.Lane 6 : Human fetal heart lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 65 kDa.
Immunocytochemistry/ Immunofluorescence - Anti-DcR1 antibody [EPR6162]; Immunofluorescent analysis of A549 cells labelling DcR1 with TA310396 at 1/100 dilution.