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Home Antibody All anti-DcR1 antibodies

Anti-DcR1 Antibody EPR6162

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310396
  • Rabbit Monoclonal antibody against DcR1
100ul $325 3-7 Days
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WB(1)
IF(1)
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Also for DcR1 (NM_003841)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human DcR1 was used as an immunogen.
Clone NameEPR6162 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250; FC: 1:100 - 1:500
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C)
Alternative NameCD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID
Database LinkNP_003832
FunctionDcR1 is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. DcR1 is not capable of inducing apoptosis, and it is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. It was found to be a p53-regulated DNA damage-inducible protein. The expression of DcR1 was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL (1).
Related Pathway
Cytokine-cytokine receptor interaction

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WB Image
Western blot - Anti-DcR1 antibody [EPR6162]; All lanes : Anti-DcR1 antibody [EPR6162] at 1/1000 dilution.Lane 1 : Human spleen lysate.Lane 2 : JAR cell lysate.Lane 3 : Human tonsil lysate.Lane 4 : Jurkat cell lysate.Lane 5 : A549 cell lysate.Lane 6 : Human fetal heart lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 65 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-DcR1 antibody [EPR6162]; Immunofluorescent analysis of A549 cells labelling DcR1 with TA310396 at 1/100 dilution.

 

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