The DUX4 antibody, clone E5-5, was recently described in the publication called "Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene." (Snider L et al. PLoS Genet. 2010 Oct 28;6(10):e1001181).
DUX4, also known as double homeobox 4, contains two homeoboxes; the repeat-array and open reading frame (ORF) is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries; however, RT-PCR and in-vitro expression experiments indicate that DUX4 has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1. Mutations in DUX4 cause autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) (1).
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