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Home Antibody All anti-DUSP3 antibodies

Anti-DUSP3 Antibody EPR5492

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310430
  • Rabbit Monoclonal antibody against DUSP3
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401320) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(2)
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Also for DUSP3 (NM_004090)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human DUSP3 was used as an immunogen.
Clone NameEPR5492 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50000 - 1:200000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens dual specificity phosphatase 3 (DUSP3)
Alternative NameVHR
Database LinkNP_004081
FunctionDUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP3 maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that it is not BRCA1 (1).
Related Pathway
MAPK signaling pathway

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WB Image
Western blot - Anti-DUSP3 antibody [EPR5492]; All lanes : Anti-DUSP3 antibody [EPR5492] at 1/50000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : MCF-7 cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 20 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DUSP3 antibody [EPR5492]; TA310430, at 1/100, staining DUSP3 in paraffin-embedded Human ovarian cancer tissue by immunohistochemistry.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DUSP3 antibody [EPR5492]; TA310430, at 1/100, staining DUSP3 in paraffin-embedded Mouse kidney tissue by immunohistochemistry.

 

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