OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-DUSP3 antibodies

Anti-DUSP3 Antibody

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308662
  • Rabbit Polyclonal antibody to DUSP3 (dual specificity phosphatase 3)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401320) , 20ug Explanation
100ul 325 3-7 Days
Add to Shopping Cart
spacer
WB(2)
IHC(1)
spacer
Also for DUSP3 (NM_004090)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 1 and 185 of DUSP3 (Uniprot ID#P51452)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Rhesus Monkey) Concentration0.58mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 20kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rhesus Monkey (100%)

Reference Data

Target NameHomo sapiens dual specificity phosphatase 3 (DUSP3)
Alternative NameVHR
Database LinkNP_004081
Entrez Gene 1845 Human
Entrez Gene 72349 Mouse
Entrez Gene 713686 Monkey
FunctionThe protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq]
Related PathwayPhosphataseDruggable Genome MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (50 ug of whole cell lysate). A: mouse stomach. 12% SDS PAGE. TA308662 diluted at 1:1000.
WB Image
DUSP3 antibody detects DUSP3 protein by western blot analysis. Various whole cell extracts (30 ug) were separated by 15 % SDS-PAGE, and blotted with DUSP3 antibody (TA308662) diluted by 1:1000
IHC Image
Immunohistochemical analysis of paraffin-embedded N87 xenograft, using DUSP3(TA308662) antibody at 1:500 dilution.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title