Home Antibody All anti-DUSP3 antibodies
Also for DUSP3 (NM_004090)
|Recombinant fragment corresponding to a region within amino acids 1 and 185 of DUSP3 (Uniprot ID#P51452)|
|Human, Mouse (Predicted: Rhesus Monkey)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Rhesus Monkey (100%)
|Homo sapiens dual specificity phosphatase 3 (DUSP3)|
Entrez Gene 1845 Human
Entrez Gene 72349 Mouse
Entrez Gene 713686 Monkey
|The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq]|
|PhosphataseDruggable Genome MAPK signaling pathway|
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Sample (50 ug of whole cell lysate). A: mouse stomach. 12% SDS PAGE. TA308662 diluted at 1:1000.
DUSP3 antibody detects DUSP3 protein by western blot analysis. Various whole cell extracts (30 ug) were separated by 15 % SDS-PAGE, and blotted with DUSP3 antibody (TA308662) diluted by 1:1000
Immunohistochemical analysis of paraffin-embedded N87 xenograft, using DUSP3(TA308662) antibody at 1:500 dilution.