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Anti-DSP Antibody EPR4383(2)
Also for DSP (NM_001008844)
|A synthetic peptide corresponding to residues in human Desmoplakin was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens desmoplakin (DSP), transcript variant 2|
|DCWHKTA; DP; DPI; DPII|
Entrez Gene 1832 Human
Entrez Gene 306871 Rat
|Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus (1). |
|Druggable Genome Arrhythmogenic right ventricular cardiomyopathy (ARVC)|
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Western blot - Desmoplakin antibody [EPR4383(2)]; All lanes : Anti-Desmoplakin antibody [EPR4383(2)] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : HACAT cell lysate.Lane 3 : BXPC-3 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 332 kDa.
Immunocytochemistry/ Immunofluorescence - Desmoplakin antibody [EPR4383(2)]; Immunofluorescent staining of Desmoplakin in A431 cells using TA310428 at 1/100 dilution.