Anti-DSP Antibody, EPR4383(2)

Also for DSP (NM_001008844)

Gene Name	Homo sapiens desmoplakin (DSP), transcript variant 2
Synonyms:	DP; DPI; DPII
Immunogen	A synthetic peptide corresponding to residues in human Desmoplakin was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR4383(2)	Isotype
Species Reactivity	Human, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IF	Suggested Dilutions	WB: 1:1,000 - 10,000; IHC 1:250 - 500;
Background	Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus (1).
Related Pathway

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WB Image

Western blot analysis on (A) A431, (B) HACAT, and (C) BXPC-3 cell lysates using anti-Desmoplakin RabMAb.

IF Image

Immunofluorescent staining of A431 cells using anti-Desmoplakin RabMAb.

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Anti-DSP Antibody EPR4383(2)

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