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Home Antibody All anti-DSC2 antibodies

Anti-DSC2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307897
  • Rabbit polyclonal antibody to Desmocollin 2 (desmocollin 2)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417636) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for DSC2 (NM_004949)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 480 and 706 of Desmocollin 2 (Uniprot ID#Q02487)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse) Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 94kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (80%)

Reference Data

Target NameHomo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b
Alternative NameARVD11; CDHF2; DG2; DGII/III; DSC3
Database LinkNP_004940
Entrez Gene 1824 Human
Entrez Gene 13506 Mouse
FunctionThe protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq]
Related PathwayTransmembrane Arrhythmogenic right ventricular cardiomyopathy (ARVC)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Desmocollin 2 antibody [C1C2], Internal detects Desmocollin 2 protein by western blot analysis. Whole cell extracts (30 ug) was separated by 7.5 % SDS-PAGE, and blotted with Desmocollin 2 antibody [C1C2], Internal (TA307897) diluted by 1:500
IHC Image
Immunohistochemical analysis of paraffin-embedded OVCAR3 xenograft , using Desmocollin 2 (TA307897) antibody at 1:500 dilution.

 

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