Home Antibody All anti-DSC2 antibodies
Also for DSC2 (NM_004949)
|Recombinant fragment corresponding to a region within amino acids 480 and 706 of Desmocollin 2 (Uniprot ID#Q02487)|
|Human (Predicted: Mouse)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (80%)
|Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b|
|ARVD11; CDHF2; DG2; DGII/III; DSC3|
Entrez Gene 1824 Human
Entrez Gene 13506 Mouse
|The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq]|
|Transmembrane Arrhythmogenic right ventricular cardiomyopathy (ARVC)|
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Desmocollin 2 antibody [C1C2], Internal detects Desmocollin 2 protein by western blot analysis. Whole cell extracts (30 ug) was separated by 7.5 % SDS-PAGE, and blotted with Desmocollin 2 antibody [C1C2], Internal (TA307897) diluted by 1:500
Immunohistochemical analysis of paraffin-embedded OVCAR3 xenograft , using Desmocollin 2 (TA307897) antibody at 1:500 dilution.