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Also for DSC2 (NM_004949)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 480 and 676 of Desmocollin 2|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens desmocollin 2 (DSC2), transcript variant Dsc2b|
|ARVD11; CDHF2; DG2; DGII/III; DSC3|
|The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq]|
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Sample (30 ug of whole cell lysate) A: A431 (anti-DSC2 antibody diluted at 1:500)
Immunohistochemical analysis of paraffin-embedded OVCAR3 xenograft , using Desmocollin 2 (anti-DSC2 antibody) antibody at 1:500 dilution.