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Home Antibody All anti-DRAM antibodies

Anti-DRAM Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306390 Rabbit Polyclonal DRAM Antibody 100ug $325 3-7 Days
LC402672 DRAM1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenDRAM antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DRAM.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens DNA-damage regulated autophagy modulator 1 (DRAM1)
Alternative NameDRAM
Database LinkNP_060840
Entrez Gene 55332 Human
Entrez Gene 71712 Mouse
Entrez Gene 679937 Rat
FunctionDamage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of DRAM in 293 cell lysate with DRAM antibody at (A) 0.5 and (B) 1 ug/ml.
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Immunohistochemistry of DRAM in human liver tissue with DRAM antibody at 2.5 ug/ml.
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