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Home Antibody All anti-DNMT3L antibodies

Anti-DNMT3L Antibody S117-9

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326396
  • Mouse monoclonal Dnmt3L Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402250) , 20ug Explanation
100µg 325 3-7 Days
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WB(1)
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Also for DNMT3L (NM_013369)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenFusion protein amino acids 1-387 of human DNMT3L
Clone NameS117-9 IsotypeIgG1
Species ReactivityHuman Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects ~45kDa. No cross-reactivity against DNMT3a or DNMT3B.

Reference Data

Target NameHomo sapiens DNA (cytosine-5-)-methyltransferase 3-like (DNMT3L), transcript variant 1
Alternative NameMGC1090
Database LinkNP_037501
Entrez Gene 29947 Human
FunctionMethylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue . Studies show that DNMT3L regulates the activity of DNMT3A and DNMT3B and stimulates their catalytic activities . DNMT3L has specifically been linked to the process of carcinogenesis, thru its role in nuclear programming .
Related PathwayTranscription FactorsDruggable Genome Cysteine and methionine metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DNMT3L in a human tissue mix using a 1:1000 dilution of the antibody

 

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