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Home Antibody All anti-DNMT3A antibodies

Anti-DNMT3A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301633
  • Rabbit Polyclonal Antibody against DNMT3a
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411621) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for DNMT3A (NM_022552)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis antibody was raised against amino acids 10-118 of the human DNMT3a protein.
Clone Name IsotypeIgG
Species Reactivityhuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1: 1000
Buffer

Reference Data

Target NameHomo sapiens DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A), transcript variant 3
Alternative NameDNMT3A2; M.HsaIIIA; TBRS
Database LinkNP_072046
FunctionInactivation of tumor suppressor genes is a key component of the development of all common forms of human cancers. Aberrant methylation may contribute to many of the changes, both physiological and pathological, associated with aging, including tumor development. Hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor angiogenesis and progression. DNA methytransferase (DNMT3a) is necessary for the maintenance of the methylation process.
Related Pathway

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WB Image
Western blot analysis to detect overexpressed DNMT3A level in HCT-116 cells. Lane 1: 40 ug of nuclear extract from untreated HCT-116 cells. Lane 2: 40 ug of Nuclear extract from HCT-116 cells overexpressing DNMT3A.
IHC Image
Immunohistochemistry: Dnmt3a antibody was tested in human testis using DAB with hematoxylin counterstain.
IF Image
Immunocytochemistry/Immunofluorescence: Dnmt3a antibody was tested in Ntera-2 cells with Dylight 488 (green). Nuclei and beta-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

 

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