Home Antibody All anti-DNMT3A antibodies
Also for DNMT3A (NM_022552)
|This antibody was raised against amino acids 10-118 of the human DNMT3a protein.|
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1: 1000
|Homo sapiens DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A), transcript variant 3|
|DNMT3A2; M.HsaIIIA; TBRS|
Entrez Gene 1788 Human
|Inactivation of tumor suppressor genes is a key component of the development of all common forms of human cancers. Aberrant methylation may contribute to many of the changes, both physiological and pathological, associated with aging, including tumor development. Hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor angiogenesis and progression. DNA methytransferase (DNMT3a) is necessary for the maintenance of the methylation process. |
|Druggable Genome Cysteine and methionine metabolismMetabolic pathways|
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Western blot analysis to detect overexpressed DNMT3A level in HCT-116 cells. Lane 1: 40 ug of nuclear extract from untreated HCT-116 cells. Lane 2: 40 ug of Nuclear extract from HCT-116 cells overexpressing DNMT3A.
Immunohistochemistry: Dnmt3a antibody was tested in human testis using DAB with hematoxylin counterstain.
Immunocytochemistry/Immunofluorescence: Dnmt3a antibody was tested in Ntera-2 cells with Dylight 488 (green). Nuclei and beta-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).