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Anti-DNAJB1 Antibody 3B9.E6
Also for DNAJB1 (NM_006145)
|Recombinant Protein Hsp40 (Hdj1)|
|Human, Mouse, Rat. Other species not tested yet.
|PBS pH7.2, 50% glycerol, 0.09% sodium azide |
|Protein G Purified
|Detects ~40kDa. Does not cross-react with HDJ2 or YDJ1.
|Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1), transcript variant 1|
|Hdj1; Hsp40; HSPF1; RSPH16B; Sis1|
|Human Hsp40/DnaJ proteins comprise a large protein family, members of which feature the J domain (named after the bacterial DnaJ protein) . The J-domain spans the first 75 N-terminal amino acids and is separated from the C-terminal by a glycine/phenylalanine-rich domain . Members of the Hsp40/DnaJ family play diverse roles in many cellular processes, such as folding, translocation, degradation and assembly of multi-protein complexes. In particular, Hdj1, the first human Hsp40/DnaJ protein identified, plays an important role in protein translation and folding, as well as in the regulation of Hsp70 function . HSP40 stimulates the ATPase activity of HSP70 which in turn causes conformational changes of the unfolded proteins . The Hsp40-Hsp70-unfolded protein complex further binds to co-chaperones Hip, Hop and HSP90 which leads to protein folding, or components of protein degradation machinery CHIP and BAG-1 . Some studies have shown that the difference between HDJ1 and type 1 DNAJ proteins including HDJ2 and yeast YdjI is the result of the possession of a zinc finger domain by the latter, which helps in the function of protein folding. .|
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Hsp40 HDJ1 visulaized using the antibody