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Home Antibody All anti-DLGAP3 antibodies

Anti-DLGAP3 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306507 Rabbit Polyclonal SAPAP3 Antibody 100ug $325 In Stock
LC421635 DLGAP3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenSAPAP3 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human SAPAP3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens discs, large (Drosophila) homolog-associated protein 3 (DLGAP3)
Alternative NameDAP3; SAPAP3
Database LinkNP_001073887
Entrez Gene 58512 Human
Entrez Gene 242667 Mouse
Entrez Gene 286923 Rat
FunctionSAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist.
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of SAPAP3 in rat brain tissue lysate with SAPAP3 antibody at (A) 1 (B) 2 ug/ml.
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Immunohistochemical staining of human brain tissue using SAPAP3 antibody at 2.5 ug/ml.
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