Postsynaptic Density protein 95 (PSD95) belongs to the membrane-associated guanylate kinase (MAGUK) family. PSD contains receptors with associated signaling- and scaffolding-proteins that organize signal-transduction pathways near the post-synaptic membrane (2). As a scaffolding protein, PSD95 controls of receptor trafficking during synaptic plasticity by anchoring synaptic proteins. PSD95 is necessary in synaptic plasticity associated with NMDA receptor signaling (1). After hetermultimerization with DLG2, PSD95 associates with cytoplasmic tail of NMDA receptor subunit and potassium channel clusters. PSD95 has been linked to autism, drug addiction, learning and memory, with its phosphorylation being critical for regulation of its function (3).
Wnt Signaling Pathway
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