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Anti-DLG4 PHOSPHO Antibody EPR2618Y


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SKU Description Amount Price Availability*  
TA307545 Rabbit monoclonal antibody against PSD95 Phospho (pS418) (clone EP2138Y ) (Phospho-Specific) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding serine 418 of human PSD95 was used as immunogen.
Clone NameEPR2618Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500
Predicted MW Explanation 95 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens discs large homolog 4 (DLG4), transcript variant 1
Alternative NamePSD95; SAP-90; SAP90
Database LinkNP_001356
Entrez Gene 1742 Human
Entrez Gene 13385 Mouse
Entrez Gene 29495 Rat
FunctionPostsynaptic Density protein 95 (PSD95) belongs to the membrane-associated guanylate kinase (MAGUK) family. PSD contains receptors with associated signaling- and scaffolding-proteins that organize signal-transduction pathways near the post-synaptic membrane (2). As a scaffolding protein, PSD95 controls of receptor trafficking during synaptic plasticity by anchoring synaptic proteins. PSD95 is necessary in synaptic plasticity associated with NMDA receptor signaling (1). After hetermultimerization with DLG2, PSD95 associates with cytoplasmic tail of NMDA receptor subunit and potassium channel clusters. PSD95 has been linked to autism, drug addiction, learning and memory, with its phosphorylation being critical for regulation of its function (3).
Related PathwayDruggable Genome Huntington's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PSD95 (phospho S418) antibody [EPR2618Y]; All lanes : Anti-PSD95 (phospho S418) antibody [EPR2618Y] at 1/500 dilution.Lane 1 : Rat brain tissue cell lysates, untreated.Lane 2 : Rat brain tissue cell lysates, treated with AP.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit-HRP at 1/1000 dilution.developed using the ECL technique.Predicted band size : 95 kDa.Observed band size : 95 kDa.


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