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Anti-DLG4 PHOSPHO Antibody EPR2618Y
Also for DLG4 (NM_001365)
|A synthetic phospho-peptide corresponding to residues surrounding serine 418 of human PSD95 was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens discs, large homolog 4 (Drosophila) (DLG4), transcript variant 1|
|PSD95; SAP-90; SAP90|
Entrez Gene 1742 Human
Entrez Gene 13385 Mouse
Entrez Gene 29495 Rat
|Postsynaptic Density protein 95 (PSD95) belongs to the membrane-associated guanylate kinase (MAGUK) family. PSD contains receptors with associated signaling- and scaffolding-proteins that organize signal-transduction pathways near the post-synaptic membrane (2). As a scaffolding protein, PSD95 controls of receptor trafficking during synaptic plasticity by anchoring synaptic proteins. PSD95 is necessary in synaptic plasticity associated with NMDA receptor signaling (1). After hetermultimerization with DLG2, PSD95 associates with cytoplasmic tail of NMDA receptor subunit and potassium channel clusters. PSD95 has been linked to autism, drug addiction, learning and memory, with its phosphorylation being critical for regulation of its function (3). |
|Druggable Genome Huntington's disease|
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Western blot - PSD95 (phospho S418) antibody [EPR2618Y]; All lanes : Anti-PSD95 (phospho S418) antibody [EPR2618Y] at 1/500 dilution.Lane 1 : Rat brain tissue cell lysates, untreated.Lane 2 : Rat brain tissue cell lysates, treated with AP.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit-HRP at 1/1000 dilution.developed using the ECL technique.Predicted band size : 95 kDa.Observed band size : 95 kDa.