This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Wnt Signaling Pathway
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Western blot analysis on (A, B) human brain tissue lysate and rat brain lysate (C, D) using anti-phospho PSD95 (pS295) RabMAb (TA303850), 1:20,000 dilution. Cells were either (A, C) treated (B, D) untreated with LP
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