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Home Antibody All anti-DIS3 antibodies

Anti-DIS3 Antibody Polyclonal


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319839 Rabbit Polyclonal DIS3 Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenDIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/mL
Predicted MW Explanation Predicted: 105 kDa Observed: 103 kDa
BufferDIS3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification DIS3 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens DIS3 exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 1
Alternative Name2810028N01Rik; dis3p; EXOSC11; KIAA1008; RRP44
Database LinkNP_055768
Entrez Gene 22894 Human
Entrez Gene 72662 Mouse
Entrez Gene 306103 Rat
FunctionDIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
Related Pathway RNA degradation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DIS3 in human ovary tissue lysate with DIS3 antibody at 1 ug/mL.

IHC Image
Immunohistochemistry of DIS3 in mouse testis tissue with DIS3 antibody at 2.5 ug/mL.

IF Image
Immunofluorescence of DIS3 in mouse testis tissue with DIS3 antibody at 20 ug/mL.


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