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Anti-DIS3 Antibody Polyclonal
Also for DIS3 (NM_014953)
|DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml
|Predicted: 105 kDa Observed: 103 kDa
|DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.|
|DIS3 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens DIS3 exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 1|
|2810028N01Rik; dis3p; EXOSC11; KIAA1008; RRP44|
Entrez Gene 22894 Human
Entrez Gene 72662 Mouse
Entrez Gene 306103 Rat
|DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.|
| RNA degradation|
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Western blot analysis of DIS3 in human ovary tissue lysate with DIS3 antibody at 1 ug/mL.