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Home Antibody All anti-DHX58 antibodies

Anti-DHX58 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306480
  • Rabbit Polyclonal LGP2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411351) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for DHX58 (NM_024119)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenLGP2 antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human LGP2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens DEXH (Asp-Glu-X-His) box polypeptide 58 (DHX58)
Alternative NameD11LGP2; D11lgp2e; LGP2; RLR-3
Database LinkNP_077024
FunctionAnti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
Related Pathway

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WB Image
Western blot analysis of LGP2 in rat kidney tissue lysate with LGP2 antibody at (A) 1 and (B) 2 µg/ml.

 

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