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Anti-DFFA Antibody EPR4222(2)
Also for DFFA (NM_004401)
|A synthetic peptide corresponding to residues in human DFF45/DFF35 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10000 - 1:50000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1|
|DFF-45; DFF1; ICAD|
|DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kDa (DFF40) and 45-kDa (DFF45) subunits. DFF45 is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFF45 is cleaved by caspase-3. The cleaved fragments of DFF45 dissociate from DFF40, the active component of DFF. DFF40 has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. DFF35 is the short isoform of DFF45.|
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Western blot - ICAD antibody [EPR4222(2)]; All lanes : Anti-ICAD antibody [EPR4222(2)] at 1/10000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : U937 cell lysate.Lane 3 : A431 cell lysate.Lane 4 : A549 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 37 kDa.