Homo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1
Synonyms:
DFF-45; DFF1; ICAD
Immunogen
A synthetic peptide corresponding to residues in human DFF45/DFF35 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kDa (DFF40) and 45-kDa (DFF45) subunits. DFF45 is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFF45 is cleaved by caspase-3. The cleaved fragments of DFF45 dissociate from DFF40, the active component of DFF. DFF40 has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. DFF35 is the short isoform of DFF45.
Related Pathway
Apoptosis
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