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Home Antibody All anti-DFFA antibodies

Anti-DFFA Antibody EPR4221

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307301
  • Rabbit monoclonal antibody against DFF45(clone EPR4221)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418008) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for DFFA (NM_004401)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminal region of human DFF45 was used as an immunogen.
Clone NameEPR4221 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1
Alternative NameDFF-45; DFF1; ICAD
Database LinkNP_004392
FunctionDNA fragmentation factor (DFF) is a heterodimeric protein of 40-kDa (DFF40) and 45-kDa (DFF45) subunits. DFF45 is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFF45 is cleaved by caspase-3. The cleaved fragments of DFF45 dissociate from DFF40, the active component of DFF. DFF40 has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.
Related Pathway
Apoptosis

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-ICAD antibody [EPR4221]; All lanes : Anti-ICAD antibody [EPR4221] at 1/10000 dilution.Lane 1 : Jurkat cell lysates .Lane 2 : U937 cell lysates .Lane 3 : A431 cell lysates .Lane 4 : HeLa cell lysates .Lysates/proteins at 10 µg per lane.Predicted band size : 37 kDa.

 

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