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Anti-DFFA Antibody EPR4221
Also for DFFA (NM_004401)
|A synthetic peptide corresponding to residues on the C-terminal region of human DFF45 was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000; IP: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF or IHC-P.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
|Homo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1|
|DFF-45; DFF1; ICAD|
|DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kDa (DFF40) and 45-kDa (DFF45) subunits. DFF45 is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFF45 is cleaved by caspase-3. The cleaved fragments of DFF45 dissociate from DFF40, the active component of DFF. DFF40 has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis.|
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Western blot - Anti-ICAD antibody [EPR4221]; All lanes : Anti-ICAD antibody [EPR4221] at 1/10000 dilution.Lane 1 : Jurkat cell lysates .Lane 2 : U937 cell lysates .Lane 3 : A431 cell lysates .Lane 4 : HeLa cell lysates .Lysates/proteins at 10 µg per lane.Predicted band size : 37 kDa.