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Home Antibody All anti-DEDD2 antibodies

Anti-DEDD2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306113
  • Rabbit Polyclonal DEDD2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC408867) , 20ug
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenDEDD2 antibody was raised against a peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Immunoaffinity chromatography purified IgG

Reference Data

Target NameHomo sapiens death effector domain containing 2 (DEDD2), transcript variant 1
Alternative NameFLAME-3
Database LinkNP_579874
FunctionApoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain (1). A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD (2). More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD (2,3). Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis (3). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DEDD2 in RAW264.7 cell lysate with DEDD2 antibody at (A) 0.5, (B) 1 and (C) 2 &#956g/ml.

 

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