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Home Antibody All anti-DDIT4 antibodies

Anti-DDIT4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306543
  • Rabbit Polyclonal RTP801 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402731) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for DDIT4 (NM_019058)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRTP801 antibody was raised against a 14 amino acid peptide from near the amino terminus of human RTP801.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 2 - 4 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens DNA-damage-inducible transcript 4 (DDIT4)
Alternative NameDig2; REDD-1; REDD1
Database LinkNP_061931
Entrez Gene 54541 Human
Entrez Gene 74747 Mouse
Entrez Gene 140942 Rat
FunctionRTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Related Pathway mTOR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RTP801 in 293 cell lysate with RTP801 antibody at (A) 2 and (B) 4 µg/ml.

 

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