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Home Antibody All anti-DDIT4 antibodies

Anti-DDIT4 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306539 Rabbit Polyclonal RTP801 Antibody 100ug $325 3-7 Days
LC402731 DDIT4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for DDIT4 (NM_019058)
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OriGene Data

ImmunogenRTP801 antibody was raised against a 12 amino acid peptide from near the center of human RTP801.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens DNA-damage-inducible transcript 4 (DDIT4)
Alternative NameDig2; REDD-1; REDD1
Database LinkNP_061931
Entrez Gene 54541 Human
Entrez Gene 74747 Mouse
Entrez Gene 140942 Rat
FunctionRTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Related Pathway mTOR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of RTP801 in human kidney tissue lysate with RTP801 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of RTP801 in mouse kidney tissue with RTP801 antibody at 5 ug/ml.


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