Home Antibody All anti-DDIT4 antibodies
Also for DDIT4 (NM_019058)
|RTP801 antibody was raised against a 12 amino acid peptide from near the center of human RTP801.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens DNA-damage-inducible transcript 4 (DDIT4)|
|Dig2; REDD-1; REDD1|
Entrez Gene 54541 Human
Entrez Gene 74747 Mouse
Entrez Gene 140942 Rat
|RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.|
| mTOR signaling pathway|
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Western blot analysis of RTP801 in human kidney tissue lysate with RTP801 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of RTP801 in mouse kidney tissue with RTP801 antibody at 5 ug/ml.