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Home Antibody All anti-DDIT4 antibodies

Anti-DDIT4 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306539 Rabbit Polyclonal RTP801 Antibody 100ug $325 3-7 Days
LC402731 DDIT4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for DDIT4 (NM_019058)
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OriGene Data

ImmunogenRTP801 antibody was raised against a 12 amino acid peptide from near the center of human RTP801.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/mL, ICC: 5 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens DNA-damage-inducible transcript 4 (DDIT4)
Alternative NameDig2; REDD-1; REDD1
Database LinkNP_061931
Entrez Gene 54541 Human
Entrez Gene 74747 Mouse
Entrez Gene 140942 Rat
FunctionRTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Related Pathway mTOR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RTP801 in human kidney tissue lysate with RTP801 antibody at (A) 0.5 and (B) 1 ug/ml.

IHC Image
Immunohistochemistry of RTP801 in mouse kidney tissue with RTP801 antibody at 5 ug/ml.


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