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Anti-DDA1 Antibody Polyclonal
Also for DDA1 (NM_024050)
|DDA1 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DDA1.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|DDA Antibody is supplied in PBS containing 0.02% sodium azide.|
|DDA Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens DET1 and DDB1 associated 1 (DDA1)|
|DDA Antibody: DDA1 (DET1 and DDB1 associated 1), along with DET1 and DDB1 and a member of the UBE2E group of canonical ubiquitin-conjugating enzymes, comprise DDD-E2 complexes, which interact with multiple ubiquitin E3 ligases. One of these E3 ligases is Cul4-containing E3 ligase complex CRL4. Cells depleted of DDA1 spontaneously accumulate double-stranded DNA breaks in a similar fashion as Cul4A-, Cul4B-, or WDR23-depleted cells, suggesting that DDA1 interacts with the CRL4 complex and may be involved in the ubiquitination and subsequent proteasomal degradation of target proteins.|
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Western blot analysis of DDA1 in mouse heart tissue lysate with DDA1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide
Immunohistochemistry of DDA1 in mouse heart tissue with DDA1 antibody at 5 ug/mL.