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Anti-DCX TRUEMAB Antibody Clone OTI4A3
TrueMAB Antibodies - Made against Authentic Protein Antigens
|Full length human recombinant protein of human DCX (NP_835365) produced in HEK293T cell.|
|WB, IF, FC
||WB 1:2000, IF 1:100, FLOW 1:100
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens doublecortin (DCX), transcript variant 2|
|DBCN; DC; LISX; SCLH; XLIS|
Entrez Gene 1641 Human
|This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].|
|Druggable Genome |
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCX (RC221891, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DCX.
Anti-DCX mouse monoclonal antibody (TA501778) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DCX(RC221891).
Flow cytometric Analysis of Jurkat cells, using anti-DCX antibody(TA501778),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).