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Home Antibody All anti-DCLK1 antibodies

Anti-DCLK1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306935
  • Rabbit Polyclonal DCLK1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417785) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for DCLK1 (NM_004734)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenDCLK1 antibody was raised against a 14 amino acid peptide near the amino terminus of human DCLK1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 0.5 - 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant 1
Alternative NameCL1; CLICK1; DCAMKL1; DCDC3A; DCLK
Database LinkNP_004725
Entrez Gene 9201 Human
Entrez Gene 13175 Mouse
Entrez Gene 83825 Rat
FunctionDCLK1 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK1 mRNA, like that of the homologous DCLK2 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a gene that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.
Related PathwayProtein KinaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DCLK1 in human brain tissue lysate with DCLK1 antibody at (A) 0.5 and (B) 1 ug/mL.
IHC Image
Immunohistochemistry of DLCK1 in rat brain tissue with DLCK1 antibody at 2.5 ug/mL.

 

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