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Home Antibody All anti-DAXX antibodies

Anti-DAXX Antibody E94

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA300370 Rabbit Monoclonal Antibody against DAXX (Clone E94) 100ul $325 In Stock
LC400540 DAXX HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
FC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues of human DAXX was used as immunogen. Predicted to cross-react with rat, based on sequence homology.
Clone NameE94 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB: 1:5000; IHC-P: Use at an assay dependent concentration; ICC: 1:50; FC: 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens death-domain associated protein (DAXX), transcript variant 2
Alternative NameBING2; DAP6; EAP1
Database LinkNP_001341
Entrez Gene 1616 Human
FunctionDaxx is a nuclear protein that has been found to the enhance Fas-mediated apoptosis and activate the JNK pathway (1). Apoptosis signal-regulating kinase 1 (ASK1) controls the dual function of Daxx as a transcriptional repressor in the nucleus and as a proapoptotic signal mediator in the cytoplasm (2). Daxx associates with various proteins, including promyelocytic leukemia protein (PML) and heat shock protein 27, lending significance to their roles in tumor suppression and Daxx-mediated apoptosis (3,4).
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome MAPK signaling pathwayAmyotrophic lateral sclerosis (ALS)

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Daxx antibody [E94]; Anti-Daxx antibody [E94] at 1/5000 dilution + Hela cell lysate.Predicted band size : 81 kDa.Observed band size : 100 kDa .Additional bands at : 48 kDa. We are unsure as to the identity of these extra bands.
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Immunohistochemistry (Paraffin-embedded sections) - Daxx antibody [E94]; Ab32140, at a dilution of 1/50, staining Daxx in paraffin embedded human stomach adenocarcinoma tissue by Immunohistochemistry.
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Flow Cytometry - Anti-Daxx antibody; Overlay histogram showing HeLa cells stained with TA300370 (red line). The secondary antibody used was Alexa Fluor 488 goat anti-rabbit IgG (H&L) at 1:2000. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1ug/1x10^6 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control.
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