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Home Antibody All anti-DAD1 antibodies

Anti-DAD1 Antibody

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SKU Description Amount Price Availability*  
TA306165 Rabbit Polyclonal DAD1 Antibody 100ug $325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenDAD1 antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human DAD1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens defender against cell death 1 (DAD1)
Alternative NameOST2
Database LinkNP_001335
Entrez Gene 1603 Human
Entrez Gene 13135 Mouse
FunctionDefender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death (1), a process important for normal organism development and tissue homeostasis (2). DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity (3,4). Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death (5,6). Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas (7), indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
Related PathwayTransmembraneDruggable Genome N-Glycan biosynthesisMetabolic pathways

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of DAD1 in HepG2 cell lysate with DAD1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
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Immunocytochemistry of DAD1 in HepG2 cells with DAD1 antibody at 10 ug/mL.
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