Home Antibody All anti-DAD1 antibodies
Also for DAD1 (NM_001344)
|DAD1 antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human DAD1.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens defender against cell death 1 (DAD1)|
Entrez Gene 1603 Human
Entrez Gene 13135 Mouse
|Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death (1), a process important for normal organism development and tissue homeostasis (2). DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity (3,4). Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death (5,6). Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas (7), indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.|
|TransmembraneDruggable Genome N-Glycan biosynthesisMetabolic pathways|
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Western blot analysis of DAD1 in HepG2 cell lysate with DAD1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry of DAD1 in HepG2 cells with DAD1 antibody at 10 ug/mL.