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Home Antibody All anti-Chk2 antibodies

Anti-Chk2 PHOSPHO Antibody EPR916(2)Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310326
  • Rabbit Monoclonal antibody against Chk2, pS33/35 (Phospho-specific)
100ul 325 3-7 Days
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Serine 33/35 of human Chk2 was used as immunogen. The antibody only detects Chk2 phosphorylated on Serine 33/35.
Clone NameEPR916(2)Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:2,000-20,000; IHC 1:100; ICC: 1:100 - 250;
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens checkpoint kinase 2 (CHEK2), transcript variant 2
Alternative NameCDS1; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53
Database LinkNP_665861
Entrez Gene 11200 Human
FunctionChk2 is a checkpoint kinase that plays a role in regulating cell cycle progression. In response to DNA damage and DNA replicational stress, Chk1 and Chk2 phosphorylate Cdc25C to prevent entry into mitosis (1,2). Consisting of ionizing radiation (IR), UV irradiation or hydroxyurea treatment, DNA damage induces ATM/ATR to phosphorylate Thr68 and other sites in the amino terminal domain (3). Phosphorylation at Thr68 is a prerequisite for subsequent activation steps.
Related Pathway
Cell cycle

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Chk2 (phospho S33 + S35) antibody [EPR916(2)Y]; All lanes : Anti-Chk2 (phospho S33 + S35) antibody [EPR916(2)Y] at 1/500 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate, treated with irradiation.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated Goat anti-rabbit at 1/2000 dilution.Predicted band size : 61 kDa.Observed band size : 61 kDa.

 

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