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Anti-Cdc37 PHOSPHO Antibody EPR4879
Also for Cdc37 (NM_007065)
|A phospho specific peptide corresponding to residues surrounding Serine 13 of human Cdc37 was used as an immunogen. This antibody only detects Cdc37 phosphorylated at Serine 13.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:250 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens cell division cycle 37 (CDC37)|
Entrez Gene 11140 Human
Entrez Gene 12539 Mouse
Entrez Gene 114562 Rat
|Cdc37 is a cell division cycle control protein of Saccharomyces cerevisiae. It is a molecular chaperone with specific function in cell signal transduction. It has been shown to form a complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Cdc37 is thought to play a critical role in directing Hsp90 to its target kinases (1). Phosphorylation of serine 13 is required for the biochemical function of Cdc37, namely for its kinase binding activity and its ability to stimulate the nucleotide-modulated conformational switching of Hsp90 (2).|
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Western blot - Cdc37 (phospho S13) antibody [EPR4879]; All lanes : Anti-Cdc37 (phospho S13) antibody [EPR4879].Lane 1 : Jurkat cell lysate (untreated).Lane 2 : Jurkat cell lysate (treated with Alkaline Phosphatase).Lysates/proteins at 10 ug per lane.Predicted band size : 44 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cdc37 (phospho S13) antibody [EPR4879]; TA310303, at 1/50, staining Cdc37 in paraffin-embedded human transitional cell carcinoma tissue by Immunohistochemistry.