Home Antibody All anti-CXCR6 antibodies
Also for CXCR6 (NM_006564)
|Bonzo antibody was raised against a peptide corresponding to amino acids 319 to 338 of human origin. The sequence of this peptide is identical to those of macaque and African green monkey.|
|PBS containing 0.02% sodium azide.|
|Antibody is DEAE purified
|Homo sapiens chemokine (C-X-C motif) receptor 6 (CXCR6)|
|BONZO; CD186; STRL33; TYMSTR|
Entrez Gene 10663 Human
|Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor. Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.|
|GPCRTransmembraneDruggable Genome Cytokine-cytokine receptor interactionChemokine signaling pathway|
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Western blot analysis of Bonzo in SW1353 total cells lysate with Bonzo antibody at 1:1000 dilution.