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Home Antibody All anti-CUL1 antibodies

Anti-CUL1 Antibody EPR3103Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301273
  • Rabbit Monoclonal Antibody against CUL1 (Clone EPR3103Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418561) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(4)
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Also for CUL1 (NM_003592)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human CUL1 was used as an immunogen.
Clone NameEPR3103Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2500 - 1:5000; IP: 1:10; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens cullin 1 (CUL1)
Alternative NameMGC149834; MGC149835
Database LinkNP_003583
FunctionCullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes (1). It has been shown that the SKP1, CUL1, F-box (SCF) containing pathway, although similarly used by the mammalian CUL1, is not shared by other cullin members. This implies that most cullins may use a SKP1/F-box-independent pathway to facilitate protein degradation (2). The majority of CUL1 has been found in a complex with CAND1 and ROC1, independent of SKP1 and F-box protein SKP2. Data suggests that CAND1 regulates the formation of the SCF complex, and its dissociation from CUL1 is coupled with the incorporation of F-box proteins into the SCF complex, causing their destabilization (3).
Related Pathway
Cell cycle
Delta-Notch Signaling Pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway

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WB Image
Western blot - Cullin 1 antibody [EPR3103Y]; All lanes : Anti-Cullin 1 antibody [EPR3103Y] at 1/5000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : A549 cell lysate.Lane 4 : PC12 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 90 kDa.Observed band size : 90 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cullin 1 antibody [EPR3103Y]; TA301273 at 1/100 dilution staining Cullin 1 in human cervical carcinoma by Immunohistochemistry, Paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cullin 1 antibody [EPR3103Y](TA301273); TA301273 showing positive staining in Normal tonsil tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cullin 1 antibody [EPR3103Y](TA301273); TA301273 showing positive staining in Urinary bladder transitional carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cullin 1 antibody [EPR3103Y](TA301273); TA301273 showing positive staining in Ovarian carcinoma tissue.

 

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