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Anti-CTNND1 Phospho Antibody EPR2383
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Also for CTNND1 (NM_001085458)
|A phospho-specific peptide corresponding to residues surrounding threonine 916 of human p120 Catenin was used as an immunogen. The antibody only detects p120 Catenin phosphorylated on threonine 916.|
||ICC: 1:100 - 250, IHC: 1:100 - 250, WB: 1:5,000 - 50,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens catenin (cadherin-associated protein), delta 1 (CTNND1), transcript variant 1|
|CAS; CTNND; p120; p120(CAS); p120(CTN); P120CAS; P120CTN|
|Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is one member of this Armadillo gene family of junctional plaque proteins (1-3). The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Recently it became clear that some catenins also mediate nuclear signaling (1). p120 Catenin is implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
EGFR1 Signaling Pathway
Wnt Signaling Pathway
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A. Western blot analysis on 293T cell lysates using anti-Phospho-p120 Catenin (pT916) RabMAb .
B. Immunohistochemical analysis of paraffin-embedded human ovarian carcinoma tissue using phospho-specific anti-p120 Catenin RabMAb.