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Anti-CTNNB1 PHOSPHO Antibody
Also for CTNNB1 (NM_001904)
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser33/37 conjugated to KLH|
||Lot dependent; please refer to CoA along with shipment
|100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
|Homo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1|
|armadillo; CTNNB; MRD19|
Entrez Gene 1499 Human
|The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene. |
|ES Cell Differentiation/IPSTranscription FactorsDruggable Genome Wnt signaling pathwayFocal adhesionAdherens junctionTight junctionLeukocyte transendothelial migrationMelanogenesisMore Pathways >> |
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Western blot of human embryonic kidney cell (HEK) lysate showing specific immunolabeling of the ~83k Î²-catenin phosphorylated at Ser33 and Ser37 (Upper Panel) and a pan Î²-catenin (Lower Panel). Control is a standard HEK cell lysate. GSK3 is a HEK cell lysate with glycogen synthase kinase 3Î² knocked down by SiRNA.