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Home Antibody All anti-CRYAA antibodies

Anti-CRYAA Antibody 1H3.B8

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA309282
  • Mouse Monoclonal anti-CRYAA Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424743) , 20ug
200ug $325 3-7 Days
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WB(1)
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Also for CRYAA (NM_000394)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNative Alpha Crystallin
Clone Name1H3.B8 IsotypeIgG1
Species ReactivityHuman, Mouse, Cow, Rat Concentration1mg/mL
Guaranteed Application *WB Suggested DilutionsWB, ELISA
BufferPBS pH7.2, in 50% glycerol

Reference Data

Target NameHomo sapiens crystallin, alpha A (CRYAA)
Alternative NameCRYA1; CTRCT9; HSPB4
Database LinkNP_000385
FunctionCrystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq].
Related Pathway

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WB Image
Western blot analysis of AlphaA Crystallin in bovine tissues at a 1:1000 dilution of anti-CRYAA. This blot shows absolute specificity as Left: AlphaA Crystallin, Right: AlphaB Crystallin.

 

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