OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-CRK antibodies

Anti-CRK PHOSPHO Antibody EPR269Y

div

Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301012 Rabbit Monoclonal Antibody against CRK (Clone EPR269Y) (Phospho-specific) 100ul $325 In Stock
Add to Shopping Cart
spacer
WB(1)

OriGene Data

ImmunogenA phospho specific peptide corresponding to regions surrounding Tyrosine 221 was used as an immunogen. This antibody detects proteins phosphorylated at Y221.
Clone NameEPR269Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:2000; ICC: 1:50 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens v-crk avian sarcoma virus CT10 oncogene homolog (CRK), transcript variant I
Alternative NameCRKII; p38
Database LinkNP_005197
Entrez Gene 1398 Human
FunctionCrk (p38) are adaptor proteins, composed mostly of SH2 and SH3 domains, which play a key role in cellular signaling by mediating the construction of protein complexes and also by managing cell proliferation, differentiation, and migration (1). They are critical integrators of upstream signals for cell invasion and migration in human cancer cell lines. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers (2). In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth (3). Crk associates with ERM family proteins (including ezrin, radixin, and moesin), activates RhoA, and promotes cell motility toward hyaluronic acid (4).
Related PathwayTranscription FactorsDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayFocal adhesionFc gamma R-mediated phagocytosisNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Crk p38 (phospho Y221) antibody [EPR269Y]; All lanes : Anti-Crk p38 (phospho Y221) antibody [EPR269Y] at 1/2000 dilution.Lane 1 : K562 cell lysate.Lane 2 : K562 cell lysate treated with AP.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 34 kDa.Observed band size : 34 kDa.
spacer

 

spacer
Inc 5000 Healthcare Company
All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title

Notice to Non-US Customers

ExclaimationWeb price and delivery time are for direct sales only.

Non-US customers are encouraged to contact our dedicated distributor network for quotes and streamlined ordering/delivery support.

Acknowledge