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Anti-CRADD Antibody EPR1639


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against CRADD (Clone EPR1639)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401252) , 20ug Explanation
100ul $325 3-7 Days
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Also for CRADD (NM_003805)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RAIDD was used as an immunogen.
Clone NameEPR1639 IsotypeIgG
Species ReactivityRat, Human (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; IP: 1:40; ICC: 1:100 - 1:250; FC: 1:30
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P.

Reference Data

Target NameHomo sapiens CASP2 and RIPK1 domain containing adaptor with death domain (CRADD)
Alternative NameMRT34; RAIDD
Database LinkNP_003796
Entrez Gene 8738 Human
Entrez Gene 314756 Rat
FunctionRAIDD (RIP-associated ICH-1/CED-3-homologous protein with a death domain), is a dual-domain adaptor protein that is constitutively expressed in many tissues (1, 2). RAIDD has an N-terminal caspase recruitment domain (CARD) that interacts with the CARD of caspase-2, and a C-terminal death domain (DD) that interacts with the DD in PIDD (p53-induced protein with a death domain) (3). RAIDD has been shown to mediate the recruitment of CASPASE-2 to tumour necrosis factor receptor-1 (TNF-R1) signalling complex through RIP kinase. Apart from its established role in apoptosis, RAIDD may have an additional function in cell differentiation, supported by its expression in developing organs derived from the ectoderm, like heart and kidney. In developing heart and kidney RAIDD expression patterns are reported to overlap with known zones of cell death suggesting RAIDD may be involved in apoptosis-mediated remodeling (1).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - RAIDD antibody [EPR1639]; All lanes : Anti-RAIDD antibody [EPR1639] at 1/5000 dilution.Lane 1 : Raji cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : K562 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 23 kDa.Observed band size : 23 kDa.


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