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Home Antibody All anti-COMT antibodies

Anti-COMT Antibody EPR6491(B)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310342
  • Rabbit Monoclonal antibody against COMT
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400254) , 20ug
100ul 325 3-7 Days
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WB(1)
FC(1)
Assay(1)
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Also for COMT (NM_000754)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human COMT was used as an immunogen.
Clone NameEPR6491(B) IsotypeTissue culture supernatant
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, ASSAY, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferDoes not react with Mouse. Is unsuitable for ICC,IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens catechol-O-methyltransferase (COMT), transcript variant 1
Alternative NameHEL-S-98n
Database LinkNP_000745
FunctionCatechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson's disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini (1).
Related Pathway

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WB Image
Western blot - Anti-COMT antibody [EPR6491(B)]; All lanes : Anti-COMT antibody [EPR6491(B)] at 1/1000 dilution.Lane 1 : Fetal Liver lysate .Lane 2 : A431 cell lysate .Lane 3 : MOLT4 cell lysate.Lysates/proteins at 10 µg per lane.developed using the ECL technique.Predicted band size : 30 kDa.
Assay Image
Other-Anti-COMT antibody [EPR6491(B)](TA310342); Equilibrium disassociation constant (KD)..
FC Image
Flow Cytometry - Anti-COMT antibody [EPR6491(B)]; TA310342, at 1/10 dilution staining COMT in A431 cells, (Red) compared to a nonspecific negative control antibody (Green) by Flow Cytometry.

 

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